09 February 2024 , 12:22
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An unexpected drug used to treat erectile dysfunction could play an important part in reducing the risk of Alzheimer's, according to research.
A new study conducted by UCL found that participants prescribed Viagra (sildenafil) were 18 per cent less likely to develop the illness - which causes extreme cognitive decline and memory loss. This is after other potential factors such as underlying health problems and smoking status were taken into account.
Among the men prescribed erectile dysfunction drugs, 749 developed the disease, which equals a rate of 8.1 cases per 10,000 persons-years (the number of people in the study and the amount of time they spend in the study). However, among the men who were not prescribed the drugs, 370 developed Alzheimer's disease. This corresponds to 9.7 cases per 10,000 person-years.
Does Viagra reduce Alzheimer's risk?
The little blue pills work by 'dilating blood vessels' and were first used to treat hypertension and angina. Scientists say the meds act on a 'cell signalling messenger' that has been investigated in the past for its link to memory.
Despite the promising findings, researchers say this should not be used as conclusive evidence that Viagra can prevent somebody from developing Alzheimer's. "More research is needed to confirm these findings, learn more about the potential benefits and mechanisms of these drugs and look into the optimal dosage," said lead author Dr Ruth Brauer.
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"A randomised, controlled trial with both male and female participants is warranted to determine whether these findings would apply to women as well." First author and PhD student Matthew Adesuyan added that the findings do not mean the drugs themselves were reducing the risk of Alzheimer's disease - but that they may 'point to a new way' to lower one's chance of the illness.
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Who can take Viagra?
While no medical body will prescribe Viagra to patients concerned about Alzheimer's - the study has bolstered interest in the drug. Speak to your doctor before taking medication designed for erectile dysfunction.
The NHS says 'most men aged 18 and over' can take sildenafil for ED, while adults and children over the age of one can take the medication for pulmonary hypertension. However, the tablets aren't suitable for some people and the organisation recommends speaking to your GP if you have any of the following:
- Experienced an allergic reaction to Viagra or any other medicine in the past
- Currently taking nitrates for angina
- Have a serious heart/ liver problem
- Have recently suffered a stroke or heart attack
- Have low blood pressure
- Have a rare eye disease such as pigmentosa
- Have sickle cell anaemia
- Have a deformity of your penis
- Have a stomach ulcer
- Have a problem with bleeding, such as haemophilia