Rail chaos is also expected in Cambridge, Coventry and Liverpool before members of train drivers union Aslef launch a six-day overtime ban from Monday.
Meanwhile, long delays are expected on the roads as the RAC predicts 16 million motorists will make a leisure trip by car between Friday and Monday.
Drivers are urged to avoid congestion by travelling before 9am or after 5pm - with parts of the North West, East Anglia and South West hit hardest on Monday.