Presley Gerber passed away on Sunday, according to the Los Angeles County Medical Examiner.
The former model was the only son of Crawford and businessman Rande Gerber.
Allie Jenkins, a representative for the family, said in a statement: "The family is asking for privacy during this very difficult and painful time."
Like his mother, Presley carved out a career as a model and worked for brands including Burberry, Dolce & Gabbana and Moschino.
The older brother of supermodel Kaia Gerber had spoken openly in recent years about his mental health difficulties and drug use.
In 2023 he told a podcast of his struggles with his mental health and depression, describing the condition as a "big part of my life...it’s a 24/job".
He added that he hoped to use his platform to help others struggling with their mental health.
“That’s really what I want to do: help people, whether you’re depressed, you’re struggling with something that is having a negative effect on your body. I mean it could be anything, and there’s no judgment.”
Kaia spoke of her brother’s struggles recently in an interview with American Vogue.
She said: "When something like that happens in a family, it kind of levels everyone.
"I think that’s also why I started to self-identify as the easy one and never wanted to ask for help."
In a social media post on 3 July, Cindy Crawford posted a photo of Presley as a young boy with the caption: “I’m so proud of the man you’ve become, but I’ll always remember you as my little boy! Love you”.

Deputy Editor