Timeline of key events
Here is a timeline of events relating to the crash yesterday.
Friday
8am - Reports of a crash on the M53
Emergency services were called to the motorway between junctions four and five at around 8am after the coach crashed into the central reservation and overturned. Merseyside Police and National Highways officers found the bus had overturned on the northbound carriageway of the motorway between J5 for New Chester Road to J4 for Brimstage Road.
The motorway was closed in both directions and people were asked to avoid the area.
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9am - Caldy Grange Grammar and West Kirby Grammar release statements
Both Caldy Grange Grammar and West Kirby Grammar Schools released statements confirming their school bus was involved in the M53 crash.
A spokesperson from West Kirby Grammar added: "We're actively gathering details and assisting affected students and their families.
"Support is available. If you need to talk or seek guidance, please contact the school office."
10am - Emergency services confirm '50 casualties'
A spokesperson for North West Ambulance service confirmed, a female was taken to hospital in a serious condition. Around 50 other patients, believed to be schoolchildren, were assessed at the scene.
12am - Alder Hey declare 'major incident' and major incident team step in
Alder Hey Children's Hospital has declared a "major incident", adding: "Our Emergency Department is currently extremely busy and we would also ask parents to only bring their children to the Department if it is urgent."
The major incident team also stepped in at Wirral University Teaching Hospitals. The status was de-escalated later.
2.30pm - Police announce 15-year-old girl and the driver of the bus have died
Merseyside Police held a press conference to confirm the tragic news that a schoolgirl, 15, and a driver, had died. Here is everything that was said.
Chief Superintendent Graeme Robson said two children were taken to hospital, while 50 others were taken to an Emergency Training Centre where they were medically assessed.
Eight of those 50 children were then taken to the Countess of Chester and Arrowe Park Hospitals.
Mr Robson added: "I would also like to remind people that there is an investigation underway and would ask people to refrain from posting anything on social media that could hamper that investigation and not to speculate."
3pm - No fly zone imposed
Flight restrictions affecting drones and helicopters were imposed in Bebington.
A temporary airspace restriction was in place from 12.55pm on Friday, making it an offence for any aircraft to fly below 3,500ft above sea level in a designated area (pictured), without the explicit permission of Merseyside Police.
Drone and aircraft users flying inside the Restricted Airspace that have not been granted permission will be guilty of committing an offence and could be prosecuted as well as having their equipment seized and confiscated.
The airspace restrictions will have an impact on all Aircraft Systems, including those used by the public, private companies and media.
5pm - Flowers left at West Kirby Grammar School
The mood outside West Kirby Grammar School was sombre.
At the end of the school day children were led by teachers to buses that arrived outside the school to take them back home. Pupils left the building in single file and were silent while boarding the buses.
Police officers were stationed outside the school until all the pupils had left the building. One bunch of flowers could also be seen on the school grounds.
7pm - Police give condition update on all 58 people involved in school bus crash
Merseyside Police confirmed 58 people were involved in the crash and gave an update on their conditions.
One 15-year-old girl and the driver of the bus died, with two further children being taken from the scene to Alder Hey Children's Hospital and two were taken to Arrowe Park. Police confirmed a 14-year-old boy also suffered life-changing injuries in the crash and remains in hospital.
A total of 52 people attended the emergency services training centre, 39 were discharged with no need for further treatment and 13 were treated for minor injuries and released.
9pm - Family release picture of 15-year-old Jessica Baker
Merseyside Police shared the picture, with the consent of the family and confirmed her name as Jessica Barker.
Police had previously reported she was 14 but have since confirmed she was 15-years-old.
10pm - Dad-of-two named as bus driver killed in crash
The family of a bus driver who was killed in a crash on the M53 today have named him as dad-of-two Stephen Shrimpton.
A GoFundMe Page has been launched to help his family after he left behind his partner and their two young children.
Saturday
12pm - Family pay tribute to bus driver
Stephen Shrimpton's family paid tribute to the 40-year-old bus driver in a statement released by the police.